Interactively Assisting Glaucoma Diagnosis with an Expert Knowledge-distilled Vision Transformer

Ziheng Li*, Haowen Wei*, Kuang Sun, David Li, Leyi Cui, Steven Feiner, Kaveri Thakoor

The ACM (Association of Computing Machinery) CHI conference on Human Factors in Computing Systems, 2025

System Overview

Duration: Aug 2024 – Present
Role: Project Lead, Lead Software Engineer, Experimenter, Co-First Author
Advisor: Dr. Steven K. Feiner & Dr. Kaveri Thakoor
Status: The ACM (Association of Computing Machinery) CHI conference on Human Factors in Computing Systems, 2025

Interactive Visual Cue

Interactive Visual Cue

Overview: This project aims to enhance glaucoma diagnosis using an expert knowledge-distilled Vision Transformer, providing AI-augmented insights to ophthalmologists. The system integrates deep learning with medical imaging to focus on key diagnostic features in retinal images. By interactively highlighting areas of interest, the platform facilitates a more nuanced diagnosis process, aiming to support clinical decision-making.

Key Features:

  • Expert Model: Focuses on critical diagnostic features in retinal images using a Vision Transformer distilled with expert knowledge.
  • Augmented Insights: Highlights areas of interest for ophthalmologists, aiding in the detection and diagnosis of glaucoma.
  • User Study: Conducted a user study with 15 ophthalmologists to validate the system’s utility and effectiveness in a clinical setting.

My Contributions:

  • Leadership: Spearheaded the development of both the front-end and back-end systems, ensuring seamless integration of AI and user interfaces.
  • User Study: Designed and conducted the user study with 15 ophthalmologists, gathering feedback to improve the system’s usability and diagnostic performance.
  • Experimentation: Fine-tuned the interaction design to support clinicians effectively, focusing on enhancing decision-making processes in glaucoma diagnosis.

Significance: This project demonstrates how AI can support clinical decision-making, specifically targeting glaucoma diagnosis. By combining expert knowledge with advanced machine learning techniques, the system aims to improve diagnostic accuracy and efficiency, thereby contributing to better patient outcomes.

Additional Notes: Detailed insights into this project can be found in my Master’s thesis. The paper is published in the CHI 2025 Late-Breaking Work track, showcasing the potential of AI in assisting ophthalmologists in diagnosing glaucoma more effectively.

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